A Prospective Diversity of Antibacterial Small Peptidomimetic and Quorum Sensing Mediated Drug: A Review

Abstract

AbstractThe global threat of antimicrobial resistance demands alternative tackling approaches with a unique mechanism of action. Antimicrobial peptides are currently explored widely as the potential next generation antimicrobials and anti‐infectives. They provide multiple advantages in terms of wide spectrum activity ranging from antimicrobial, anti‐infective to immunomodulatory agents. The most striking feature is the delayed resistance development. Owing to their reduced stability and easy degradation, the current research is focused on the development of small peptidomimetic molecules (SPMs) provides longer half‐life and improved stability. In addition, they are widely explored as quorum sensing inhibitors. These are proven to be effective quorum quenchers against both Gram ‐ positive and Gram – negative bacteria. Specifically these molecules are shown to have potent anti‐biofilm activity. In this regard, this review provides the structural aspects in the development of SPMs as both antibacterial and anti‐quorum drugs for the last five years.