A proposed waist-to-height ratio (WtHR) cutoff point for metabolic risk in Brazilian Turner syndrome patients

Samantha Dodt Farias,Ludmilla Aline Guimarães Moreira Farias,Eveline Gadelha Pereira Fontenele,Rosana Quezado,Camila Sâmea Monteiro Bezerra,Tamires Morita,Ana Rosa Pinto Quidute

doi:10.20513/2447-6595.2018v58n4p19-25

Samantha Dodt Farias, Ludmilla Aline Guimarães Moreira Farias + Show 5 more

Open Access

https://doi.org/10.20513/2447-6595.2018v58n4p19-25

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Abstract

Objective: To propose a waist-to-height ratio (WtHR) cutoff point for metabolic risk in Brazilian Turner syndrome (TS) patients. Methods: Retrospective study of anthropometric, clinical and biochemical data related to the metabolic syndrome (MS) of 45 TS patients at a specialized center. The accuracy and area under the receiver operating characteristic (ROC) curve of body mass index (BMI), waist circumference (WC) and WtHR to identify the presence of at least one of the biochemical components of MS were calculated. Results: The average age was 23.8 years (4-61 years), 43% were overweight and 11% had MS. At least one component of MS was present in 80% of the patients, being more common central obesity, low levels of HDL and dysglycemia. None had diabetes. Patients with some of the biochemical changes in MS had higher WtHR than those without metabolic alterations (0.57 vs. 0.48, P = 0.001). In adult patients (20-61 years, n = 28) the WtHR > 0.5 had 87% sensitivity and 80% specificity to identify patients with some component of MS, demonstrating greater accuracy than BMI or WC. Conclusion: We propose a WtHR cutoff point of 0.5 for metabolic risk screening in Brazilian TS patients.

Highlights

Retrospective study of anthropometric, clinical and biochemical data related to the metabolic syndrome (MS) of 45 Turner syndrome (TS) patients at a specialized center
A previous study demonstrated an increased waist circumference in patients with Turner syndrome, which is associated with higher risk of metabolic abnormalities.[7]
Data collected from medical records in the last medical visit were: i) age, blood pressure, height, weight, body mass index, waist circumference, waist-to-height ratio; ii) karyotype; iii) previous or current use of somatotropin; iv) previous or current use of estrogen; v) family history of diabetes, hypertension, dyslipidemia and obesity; vi) sedentary lifestyle or smoking; and vii) prevalence of metabolic syndrome or its components according to International Diabetes Federation (IDF) Task Force[10] criteria for women, during the outpatient follow-up

Summary

ARTIGO ORIGINAL

ƉƌŽƉŽƐĞĚ ǁĂŝƐƚͲƚŽͲŚĞŝŐŚƚ ƌĂƟŽ ;tƚ,ZͿ ĐƵƚŽī ƉŽŝŶƚ ĨŽƌ ŵĞƚĂďŽůŝĐƌŝƐŬŝŶƌĂnjŝůŝĂŶdƵƌŶĞƌƐLJŶĚƌŽŵĞƉĂƟĞŶƚƐ hŵĂƉƌŽƉŽƐƚĂĚĞƉŽŶƚŽĚĞĐŽƌƚĞĚĂƌĞůĂĕĆŽĐŝŶƚƵƌĂͬĂůƚƵƌĂ;ͬͿĐŽŵŽ ŵĂƌĐĂĚŽƌĚĞƌŝƐĐŽŵĞƚĂďsůŝĐŽĞŵƉĂĐŝĞŶƚĞƐĐŽŵƐşŶĚƌŽŵĞĚĞdƵƌŶĞƌ. Camila Sâmea Monteiro Bezerra[6]

Objective

Findings

Weight excess Central obesity