Abstract
Juvenile rainbow trout ( Salmo gairdneri) were exposed to 10 common industrial and agricultural chemicals in a series of acute toxicity tests to provide data for the evaluation of the test design currently employed in hazard assessment for novel chemicals in the aquatic environment. Analysis of these data revealed that the widely employed design of 10 fish at each of 5 concentrations covering one order of magnitude could be modified to one of 7 fish at each of 4 concentrations with minimal reduction in the precision of the result (i.e., the LC 50 value). The adoption of this modification to test design, however, would result in a reduction of approximately 40% of the number of experimental animals used in bioassay programmes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
