Abstract
The objective of de‐escalation for human papillomavirus‐positive oral oropharyngeal squamous cell carcinoma is well recognized, but the optimal candidates and methods are currently unknown. To answer these important questions, this commentary proposes a risk‐based and strategy‐adapted approach to de‐escalation in the form of 3 complementary randomized controlled trials that compare rationally selected de‐escalation strategies in well defined risk groups.
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