Abstract
The development of innovative drug delivery systems is currently under intense consideration to overcome bioavailability issues of poorly water-soluble drugs. Among the many existing delivery systems, self-assembled drug delivery systems (SADDS) are of great interest. Solid Lipid Nanoparticles (SLN), which are part of SADDS, have been widely studied in the pharmaceutical field since they are biodegradables and biocompatibles. However, stability of SLN suspension over time is limited and quick drug released were frequently observed. The development of solid SADDS (S- SADDS), to produce an on-demand delivery system, through a one-step production process has been designed to overcome these issues. The coupling of both Supercritical Carbon Dioxide (scCO2) assisted RESS and SAS processes (RESS/SAS) have been proposed as a proof-of-concept. This study was carried out in three steps: (i) the development and adjustment of operating conditions to produce SLN suspension using solvent injection process, (ii) the optimization of the formulation to produce SLN with a mean particle size diameter close to 100 nm and stable at least 24 h, (iii) the transposition of the SLN formulation composition into the RESS/SAS coupled process for the production of S-SADDS. SLN composed of stearic acid, PVP K30, phosphatidylcholine and nifedipine, with an average size under 100 nm and a zeta potential about −35 mV were obtained from the preliminary study. These results allowed the transposition of the optimal formulation into RESS/SAS crystallization process. The developed RESS/SAS scCO2-assisted processes demonstrate the simultaneous crystallization of a self-assembled formulation in a one step process. A control of operating conditions was also demonstrated through the generation of S- SADDS containing desired amount of nifedipine. The proof-of-concept process studied, seems to be very promising tool for the generation of complex solids, intermediate products or for the development of innovative drug delivery systems.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
