Abstract

Identifying the stage of lung cancer accurately from histopathology images and gene is very important for the diagnosis and treatment of lung cancer. Despite the substantial progress achieved by existing methods, it remains challenging due to large intra-class variances, and a high degree of inter-class similarities. In this paper, we propose a phased Multimodal Multi-scale Attention Model (MMAM) that predicts lung cancer stages using histopathology image data and gene data. The model consists of two phases. In Phase1, we propose a Staining Difference Elimination Network (SDEN) to eliminate staining differences between different histopathology images, In Phase2, it utilizes the image feature extractor provided by Phase1 to extract image features, and sends the multi-scale image features together with gene features into our Adaptive Enhanced Attention Fusion (AEAF) module for multimodal multi-scale features fusion to enable prediction of lung cancer staging. We evaluated the proposed MMAM on the TCGA lung cancer dataset, and achieved 88.51% AUC and 88.17% accuracy on classification prediction of lung cancer stages I, II, III, and IV. The method can help doctors diagnose the stage of lung cancer patients and can benefit from multimodal data.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.