Abstract
Deep brain stimulation (DBS) is one of the most effective therapies for movement and other disorders. The DBS neurosurgical procedure involves the implantation of a DBS device and a battery-operated neurotransmitter, which delivers electrical impulses to treatment targets through implanted electrodes. The DBS modulates the neuronal activities in the brain nucleus for improving physiological responses as long as an electric discharge above the stimulation threshold can be achieved. In an effort to improve the performance of an implanted DBS device, the device size, implementation cost, and power efficiency are among the most important DBS device design aspects. This study aims to present preliminary research results of an efficient stimulator, with emphasis on conversion efficiency. The prototype stimulator features high-voltage compliance, implemented with only a standard semiconductor process, without the use of extra masks in the foundry through our proposed circuit structure. The results of animal experiments, including evaluation of evoked responses induced by thalamic electrical stimuli with our fabricated chip, were shown to demonstrate the proof of concept of our design.
Highlights
In recent decades, electrical stimulation devices have been increasingly used in clinical applications [1,2,3,4] and late-stage development of many traditional “medical” disorders [5,6,7,8]
The results suggest that the ΣSSEP results and the stimulus intensities exhibited a significant linear relationship, demonstrating that our highly integrated low-cost and energy-efficient Deep brain stimulation (DBS) system is promising for the effective treatment of neurodegenerative diseases [38,39,40,41,42]
DBS has been an important surgical procedure in which a device called a neurostimulator delivers tiny electrical signals to brain areas that are related to movement control
Summary
Electrical stimulation devices have been increasingly used in clinical applications [1,2,3,4] and late-stage development of many traditional “medical” disorders [5,6,7,8]. Deep brain stimulation (DBS) has become one of the most important therapies in functional neurosurgery. The DBS device can deliver tiny electrical signals to modulate neuronal activation in the brain to improve patients’ symptoms. Scientific researchers and clinicians can employ an arbitrary waveform with a current/voltage source and/or sink to accumulate certain charge on the cells or tissues by adjusting the pulse widths. Biphasic stimulation can be utilized for charge balance for the reduction of tissue damage, it has been shown that both phases can contribute to altered neuronal activities [15]. Despite the difference in charge induction method, the resulting electrophysiological effects of mono- and bi-phasic stimulations should be identical
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