Abstract
SUMMARY Complement-fixing antibody to rinderpest virus was demonstrated in heat-inactivated cattle sera. The method used an extract of rinderpest-infected bovine lymph nodes as antigen, increasing concentrations of guinea-pig complement, and overnight fixation. By this procedure, specific complement-fixing antibody was demonstrated from 5 days after fever peak or 10 days after inoculation through at least 50 days. Sera were obtained from the cattle inoculated with lapinized Nakamura III, Kabete attenuated goat, and tissue culture attenuated Kabete O and Pendik strains of the virus. Cattle showing complement-fixing antibody resisted challenge with virulent rinderpest virus
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