Abstract
A Primary Large Cell Neuroendocrine Carcinoma of the Urinary Bladder in a 19-year-old Man Whi-An Kwon, Yun-Sok Ha, Ok-Jun Lee, Yong-June Kim, Seok-Joong Yun, Sang-Cheol Lee, Wun-Jae Kim From the Departments of Urology and Pathology, Chungbuk National University College of Medicine, Cheongju, Korea Primary large cell neuroendocrine carcinomas of the urinary bladder are extremely rare. To date, only six cases of large cell neuroendocrine carcinoma have been reported. We present a case of a 19-year-old man who presented with gross hematuria and who was subsequently found to have a solitary tumor on the dome of the urinary bladder. The patient underwent transurethral resection of the bladder tumor for histological confirmation. A diagnosis of large cell neuroendocrine carcinoma was made based upon immunohistochemical reactivity for synaptophysin and CD56. Based on the pathologic diagnosis, he subsequently had a partial cystectomy. Histologically, the tumor penetrated the perivesical fat. It has now been 6 months since the surgery, and the patient is preparing to receive his 5th cycle of chemotherapy. There is no evidence of tumor recurrence or metastasis. (Korean J Urol 2008;49:647-649)
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