Abstract
Single/double eyelids present one of the most typical oriental externally visible characteristics in Asian populations. To investigate SNPs related to eyelid phenotypes in Chinese, genotyping of 4 candidates SNPs was performed with DNA from 96 (single/double eyelids 48 respectively) healthy Chinese adults through TaqMan® probes. SNP rs2277404 on the ABCC9 gene had a significantly different distribution for C/T and T/T genotype frequencies in single/double eyelids populations (p<0.05); no difference was found for rs7316271 of the ABCC9 gene. Inconsistent genotype frequencies between single/double eyelids groups were found for SNP rs12635264 and rs1717652 on the MASP1 gene (p>0.05). More samples and genetic markers should be tested in follow-up research to predict eyelid traits with high accuracy.
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