A Primary Analysis between Estrogen Receptor-1 Gene Polymorphisms and Myasthenia Gravis

Abstract

Objective To discribe the characterestics of ESR-1 gene polymorphisms in MG patients and to explore the relationship between the polymorphisms of genotypic and allelic distributions in MG patients. Methods We collected the total blood samples of 72 MG patients and 50 young stroke patients( excluding autoimmune diseases). DNA was extracted and SSP-PCR methods were used to describe ESR-1 gene polymorphisms. The frequencies of genotype and alleles were compared among different subclasses (including gender,age,type,thymus abnormity and therapeutic effects). Results There were significant defferences between glucocorticoid( + ) group and glucocorticoid( - ) group for the genotypic distributions on condon 10 of exon 1 ( P = 0.043 ),either between the glucocorticoid( - ) group and control group( P = 0. 019). Considering the involved extents, the difference of genotype between therapeutic effect groups had no significance(P=0.096). There were no significant differences among other subclasses or between other subclasses and control group( P＞0.05 ). No significant difference was found among different subclasses for alleles on condon 10( P＞0.05 ). Condon 87 had no polymorphism because the genotype of all samples (including control group) was G/G. Conclusions There was no significant correlation between the frequency of genotypic distributions on condon 10 and 87 of ESR-1 and MG onsetting and clinical characters. Key words: Myasthenia gravis; Estrogen receptor-1 ; Gene polymorphisms