Abstract

Retinal prostheses face with the problem of low resolution in clinical trial. Current steering is an effective way to produce extra perceptual channels called virtual electrodes (VEs) and therefore improve the perceptual resolution, without increasing the number of stimulating electrodes. However, little research has been reported about applying this method to subretinal prostheses. In this study, multilayer models of normal human retina and degenerated human retina with retinitis pigmentosa (RP) were established. The configuration and parameter of stimulating electrodes were studied for generating focal VEs. Our stimulated results showed that distant sclera is a suitable site set as ground compared to distant vitreous body. Simultaneous stimulating of adjacent electrodes can generate focal VEs in the target retinal layer that subretinal prostheses prefer to stimulating, when parameters of the stimulating electrode (diameter and edge-to-edge distance) were selected appropriately. This study may provide theoretical support for future application of VEs in subretinal prostheses.

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