Abstract
Acute cerebral ischemia is an important clinical disease that is usually detected by magnetic resonance imaging or computed tomography. The magnetic inductive phase shift (MIPS) is a new method for detecting cerebral diseases, which is non-invasive, miniaturized, and low-cost. A total of 25 rabbits were studied using a two-coil sensor with a 0.3-200 MHz frequency range, and all the subjects were measured for 1 hour. Based on the rabbit acute cerebral ischemia model, the rabbits were divided into unilateral ligation, bilateral ligation, and non-ligation groups. The results showed that the average MIPS values of the non-ligation, unilateral ligation, and bilateral ligation group were -0.195 ± 0.079°, -4.873 ± 1.042°, and -9.165 ± 2.862° respectively. MIPS distinguished different severities of cerebral ischemia in rabbits with statistical significance (p <; 0.05). Laser Doppler flowmetry (LDF) was used as the gold standard for collecting cerebral blood flow data. The strong correlation between the LDF measurements and the phase shift suggested that the phase shift reflects blood flow changes in the brain. Overall, these results suggest that the MIPS detection method has the potential to provide early detection of global cerebral ischemia. Furthermore, this method effectively distinguished different severities of cerebral ischemia.
Highlights
Cerebral ischemia is a medical condition in which a certain region of the brain is deprived of oxygen and nutrient-rich blood [1]
In one of the bilaterally ligated rabbits, the intracranial pressure (ICP) remained at 15 ± 2 mmHg, and heart rate decreased from 330 ± 5 to 280 ± 7 after 60 min of ligation time
Serguei et al studied the dielectric properties of swine brain tissues with acute ischemia stroke at 1 GHz using the open-ended coaxial probe measurement technique. They demonstrated that acute ischemic stroke causes immediate changes in the dielectric properties of brain tissue, and the degree of such changes depends on the development of ischemic injury [24]
Summary
Cerebral ischemia is a medical condition in which a certain region of the brain is deprived of oxygen and nutrient-rich blood [1]. Many noninvasive detection methods are being used to measure cerebral ischemia, including magnetic resonance imaging (MRI) [4] and computed tomography (CT) [5]. These methods are disadvantageous because of their large size, high expense, and high inspection costs, but CT and MRI cannot detect early acute cerebral ischemia [4,6]. These methods do not help with emergency on-site and pre-hospital diagnoses
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