A preliminary study on the expression of human leucocyte antigen G in urothelial carcinoma after renal transplantation

Abstract

Objective To investigate the expression of human leucocyte antigen G (HLA-G) in urothelial carcinoma after renal transplantation, and to analyse the relationship between HLA-G expression and the various clinical and pathological parameters. Methods 29 patients with urothelium carcinoma after renal transplantation for the first time from January 2005 to June 2016 were selected as the experimental group, the age range was 32-70 years, with an average of (55.5±8.1)years. 29 non-transplanted patients with urothelial carcinoma as the control group 1, the age range was 36-74 years, with an average of (57.9±8.2)years. 15 cases of normal urinary tract epithelial were from cystoscopy biopsy as the control group 2. Immunohistochemical method was used to detect the difference of HLA-G expression between the three groups. The clinical and pathological data of patients with urothelial carcinoma after renal transplantation were analyzed. Results The expression rate of HLA-G was 79.3% (23/32) in patients with urothelial carcinoma after renal transplantation, 37.9% (11/32) in non-transplanted group and 0 (0/15) in normal urinary tract epithelium group. The expression rate of HLA-G in non-transplanted group was significantly higher than that in normal urinary tract epithelium group (P<0.05). The expression rate of HLA-G in patients with urothelial carcinoma after renal transplantation was significantly higher than that in non-transplanted group and normal urinary tract epithelium group (P<0.05). Conclusions HLA-G is associated with the occurrence of urothelial carcinoma after renal transplantation. It may provide a new idea for the prevention and treatment of urinary tract epithelium after renal transplantation. Key words: Human leukocyte antigen G; Renal transplantation; Urothelial carcinoma; Post-transplant malignancy