A preliminary study on prognosis of polypeptide-N-acetylgalactosaminyl transferase 3 to forecast patients with small peripheral lung adenocarcinoma

Abstract

Objective To explore the expression of UDP-N-acetyl-alpha-D-Galactosamine:polypeptide-N-acetylgalactosaminyl transferase 3 (GalNAc-T3) and prognosis factors in small peripheral lung adenocarcinoma (＜ 2 cm).Methods The clinical data of 108 patients with lung adenocarcinoma who underwent complete surgical resection were collected between January 2006 and June 2009,and had detailed clinical follow-up information.The GalNAc-T3 expression in the primary lung adenocarcinoma specimens was detected by using immunohistochemistry (IHC).The clinical characteristics and outcomes in patients were analysed.Results The rate of low expression of GalNAc-T3 was 40.7％,and its was associated with poorly differentiated tumour (P ＜ 0.05),pleural invasion (P ＜ 0.05),lymphatic invasion (P =0.05),vascular invasion (P ＜ 0.01) and Noguchi' s subtypes (P ＜ 0.01),but not with gender,ages,concentration of carcinoembryonic antigen(CEA) and pTNM (P ＞ 0.05).Univariate survival ananlysis revealed aht Noguchi' s subtypes (x2 =4.845,P ＜ 0.05),pleural invasion (x2 =15.975,P ＜ 0.01),and low expression of GalNAc-T3 (x2 =8.830,P ＜ 0.01) were correlated with prognosis.In addition,the low expression of GalNAc-T3 [relative risk (RR) =4.030,95％ confidence interval (CI):1.284-12.647) and pleural invasion (RR =0.187,95％ CI:0.063-0.550) were significant independent prognosis factors in small peripheral adenocarcinomas patients.Conclusion The low expression of GalNAc-T3 was associated with poorly differentiated tumour,pleural invasion,lymphatic invasion,vascular invasion and Noguchi's subtypes,and may be a useful marker for predicting prognosis in small peripheral adenocarcinomas patients. Key words: Polypeptide-N-acetylgalactosaminyl transferase 3; Lung adenocarcinoma; Prognosis