Abstract
Many different dietary supplements are currently marked for the management of hepatic illness, but the evidence for effectiveness is mixed. The aim of this study was to evaluate the effect of white and green tea extracts in a rifampicin-induced hepatic damage model of rats. In this study 55 male wistar albino rats were divided into 11 groups of 5 animal, named: normal control, hepatotoxic control with rifampicin (150 mg/kg), hepatotoxic with silymarin, hepatotoxic treated with green tea (250 and 500 mg/kg aqueous extract), hepatotoxic treated with white tea (250 and 500 mg/kg aqueous extract) and preventive groups of green and white tea with mentioned above doses. After 3 weeks treatment with green and white tea, a significant reduction in total cholesterol, triglyceride, LDL cholesterol, malondialdehyde and liver enzymes was observed. In the cases of white tea these changes was notable and dose-dependently improved liver function compared with green tea. The results obtained in this study suggest white tea is much more effective than green tea for prevention and treatment of drug-induced liver injury.
Highlights
Rifampicin, known as Rifampin, is an antibiotic used to treat a several types of bacterial infections and as an anti-tuberculosis drug, usually administered with other antituberculosis agents
Different types of tea are produced from fresh tea leaf (Camellia sinensis): Green, black, white, and red tea which is different in terms of production methods
The aim of this paper is to investigate the physiochemical effect of green and white tea on lipid profile, hepatic lipid peroxidationactivity, antioxidant enzyme and liver enzyme as a marker for hepatic injury in hepatotoxic rat model induced by rifampin todetermine which tea could have potentially more beneficial effect on liver status
Summary
Rifampicin, known as Rifampin, is an antibiotic used to treat a several types of bacterial infections and as an anti-tuberculosis drug, usually administered with other antituberculosis agents. Some patients experience hepatotoxic reaction after using this drug [1]. Medicinal plants have been used for the treatment of the diseases since ancient times. Tea is the most commonly consumed beverage worldwide and has been used in traditional medicine for centuries. Black and green teas are the most popular types. Different types of tea are produced from fresh tea leaf (Camellia sinensis): Green, black, white, and red tea which is different in terms of production methods. Each type of tea has its own characteristics including a different taste and different pharmacological activities [3,4,5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: American Journal of Clinical and Experimental Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
