Abstract
Chloroquine diphosphate (CD), a synthetic drug discovered by Andersag (Andersag, Breitner and Jung, 1939), has a number of interesting biological properties. One of its most important uses has been as a therapeutic drug in the treatment and prevention of malaria (Coatney, 1963). However, strains of the malarial parasite, Plasmodium falciparum, have recently proven to be almost completely resistant to CD as well as to other antimalarial drugs (WHO, 1964). Solving the problem concerning CD-resistant malaria involves understanding the basis of (1) the chemical and physical nature of the drug’s antimalarial activity and (2) Plasmodium falciparum’s resistance to CD. The physical and chemical properties of CD are now under investigation in our laboratories.
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