Abstract
Infra-renal clamping of the abdominal aorta during aneurysm repair is associated with a significant reduction in renal blood flow. Adenosine has been implicated as a mediator of renal ischemia in a number of human and animal models and its antagonism with theophylline has lead to the attenuation of these effects. In order to investigate the possible attenuation of renal arterial vasoconstriction associated with infrarenal cross clamping of the aorta we prospectively randomised 8 consecutive patients undergoing abdominal aortic aneurysm repair to receive aminophylline 5 mg/kg (n = 5) in 500 ml normal saline or placebo (n = 3) on the morning of surgery followed by an infusion of 6 mg/hour of aminophylline or placebo for 24 hours. Staff, investigators and patients were blinded. Inulin clearance as an indicator of glomerular filtration rate (GFR) was measured pre-operatively and again on the 2nd post-operative day. N-Acetyl-β-glucosaminidase (NAG) activity (mmol PNP/hour/mol creat) and Retinol Binding Protein (RBP) excretion (mg/mol creat) were measured to assess renal tubular damage and albumin excretion (mg/mol creat) as a marker of glomerular injury.
Highlights
In our experience, very often, even with a nonrebreathing mask (NRM), high oxygen delivery to patient with the existent materials is insufficient
TMSORG for R, C, N and Re were significantly associated with HM
P109 How we reduce allogenic blood transfusions in the patients undergoing surgery of ascending aorta D Radojevic, Z Jankovic, B Calija, M Jovic, B Djukanovic
Summary
Very often, even with a nonrebreathing mask (NRM), high oxygen delivery to patient with the existent materials is insufficient. There is evidence that increasing the dose of continuous renal replacement therapy (CRRT) is associated with improved survival in critically ill patients with acute renal failure (ARF) [1]. The aim of this study is to investigate if there is any difference in patients’ characteristics in ICU between COPD and nonCOPD diseases caused chronic respiratory failure and require mechanical ventilation during acute exacerbations. Noninvasive positive pressure ventilation (NPPV) has been reported to be beneficial in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD), and to facilitate weaning In this trial we assessed the possible benefit of early NPPV in patients with blunt chest trauma and acute respiratory failure. The aim of this study was to compare the pharmacokinetic and pharmacodynamic parameters and the clinical efficacy of a continuous infusion of cefepime versus an intermittent regimen in critically ill adults patients with gram negative bacilli infection. The purpose of the study is to identify the factors associated with DNR status in our institution
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