Abstract
Introduction: Over the course of the 20th century, there has been a sharp increase in the consumption of saturated fat and refined sugars. This so-called “western diet” (WD) has been extensively linked to biological alterations and associated functional deficits in the hippocampus of animals. However, the effects of a WD on the human hippocampus are less well-characterized. This preliminary study aimed to extend prior animal work by investigating the effects of a WD on hippocampal volume in children.Methods: Twenty-one healthy children (ages 5–9) completed a structural T1-weighted magnetic resonance imaging scan. Bilateral hippocampal volumes (as regions-of-interest) and bilateral amygdala volumes (as medial temporal lobe control regions-of-interest) were calculated. WD variables were derived from the parent-completed Youth/Adolescent Food Frequency Questionnaire. Specifically, variables were calculated as percent of daily calories consumed from sugars, fats, or a combination of these (WD).Results: While the relationships between overall WD consumption and bilateral hippocampal volumes were not significant, increased fat consumption was significantly related to decreased left hippocampal volume. Sugar consumption was not related to hippocampal size. Control region volumes were not related to any diet variables.Discussion: This study is the first to directly link diet—specifically fat consumption—to decreased left hippocampal volume in children. This extends previous work showing smaller left hippocampal volume related to obesity in pediatric samples. Though preliminary, findings represent an important step toward understanding the impact of diet on child brain development.
Highlights
Over the course of the 20th century, there has been a sharp increase in the consumption of saturated fat and refined sugars
A western diet” (WD) has been linked to brain functioning, including global cognitive deterioration [4, 5], while a Mediterranean diet, or a diet characterized by high consumption of olive oil and plant-based foods, has been shown be a protective factor against normal cognitive aging [6] as well as Alzheimer’s Disease [7]
Using a diet questionnaire completed by children’s parents and hippocampal volumes obtained from anatomical MRI scans, we investigated the relationship between WD consumption and hippocampal size
Summary
Over the course of the 20th century, there has been a sharp increase in the consumption of saturated fat and refined sugars. This so-called “western diet” (WD) has been extensively linked to biological alterations and associated functional deficits in the hippocampus of animals. The effects of a WD on the human hippocampus are less well-characterized. This preliminary study aimed to extend prior animal work by investigating the effects of a WD on hippocampal volume in children
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