Abstract
Background.It has been reported that a concentration ratio of two ketone bodies, [acetoacetate]/[β-hydroxybutyrate], reflects the redox state in the liver mitochondria, but there are few reports which examined each ketone body concentration during hepatectomy.Materials and Methods.(1) Ketone body levels in the radial artery and the hepatic vein were measured simultaneously during hepatectomies in 12 patients. (2) Arterial ketone body levels were measured during hepatectomies (at three points) in 73 patients.Results.(1) Both ketone body levels in the radial artery well reflected those in the hepatic vein (P< 0.001). (2) There was no change in the arterial acetoacetate level. The level of β-hydroxybutyrate increased significantly from 30.4 to 76.5 μmol/L (P< 0.005) only in the group of 25 patients with seriously impaired indocyanine green clearance test.Conclusions.Ketosis during hepatectomy was caused by increased β-hydroxybutyrate, and this phenomenon was observed only in patients with seriously impaired liver function.
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