A predictive survival model for patients with head and neck squamous cell carcinoma treated with immune check point inhibitors.

M Bonomi,M Old,P Bhateja,B Klamer,R Carrau,D Blakaj,A Blakaj,M Issa,D Mitchell,M Gamez,X Pan,L Mousa,S Kang,V Karivedu,Nolan B Seim,J Rocco

doi:10.1016/j.oraloncology.2020.104900

M Bonomi, M Old + Show 14 more

Open Access

https://doi.org/10.1016/j.oraloncology.2020.104900

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Journal: Oral oncology	Publication Date: Jul 20, 2020
Citations: 5	License type: cc-by-nc-nd

Affiliation: The Ohio State University, Yale University

Abstract

ICIs have expanded treatment options for HNSCC. A minority of the patients respond to these expensive treatments. This is a single institutional retrospective review on 121 unresectable or metastatic HNSCC patients treated with ICIs. We predicted that inflammatory markers available through routine blood work, in addition to clinical characteristics may divide patients into groups more or less likely to respond to these agents. Here we develop and internally validate our nomogram to predict survival in patients treated with ICIs.

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