A Prediction Model for High Risk of Positive RT-PCR Test Results in COVID-19 Patients Discharged From Wuhan Leishenshan Hospital, China.

Yawei Qian,Limao Zhang,Yue Pan,Yang Liu,Guang Zeng,Kun Li

doi:10.3389/fpubh.2021.778539

Abstract

Several recent studies have reported that a few patients had positive SARS-CoV-2 RNA tests after hospital discharge. The high-risk factors associated with these patients remain to be identified. A total of 463 patients with COVID-19 discharged from Leishenshan Hospital in Wuhan, China, between February 8 and March 8, 2020 were initially enrolled, and 351 patients with at least 2 weeks of follow-up were finally included. Seventeen of the 351 discharged patients had positive tests for SARS-CoV-2 RNA. Based on clinical characteristics and mathematical modeling, patients with shorter hospital stays and less oxygen desaturation were at higher risk of SARS-CoV-2 RNA reoccurrence after discharge. Notably, traditional Chinese medicine treatment offered extensive benefits to reduce risk. Particular attention should be paid to those patients with high risk, and traditional Chinese medicine should be advocated.

Highlights

In December 2019, patients with an unknown pneumonia, called coronavirus disease 2019 (COVID-19), were first identified in Wuhan, China [1,2,3]
All recovered patients with COVID-19 from Leishenshan Hospital in Wuhan, China, who met the criteria for hospital discharge were enrolled between February 8 and March 8
Leishenshan hospital was one of the makeshift hospitals used to treat and isolate patients infected with SARS-CoV-2; it was rapidly built in 1 week and was entrusted by Zhongnan Hospital of Wuhan University, China

Summary

Introduction

In December 2019, patients with an unknown pneumonia, called coronavirus disease 2019 (COVID-19), were first identified in Wuhan, China [1,2,3]. A few studies have indicated that a small number of recovered patients with COVID-19 had positive SARS-CoV-2 RNA tests [4, 5]. It is still unclear how many discharged people have true positive nucleic acid test results. Patients with a high risk of positive RT-PCR results after hospital discharge are difficult to differentiate. Patients with confirmed COVID-19 from Leishenshan Hospital in Wuhan, China, who met the hospital discharge criteria were followed up for at least 2 weeks. We aimed to investigate the real rate of positive RT-PCR test results in recovered patients and establish an exact model of predicting repositive status in discharged patients

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Conclusion