Abstract
Dementia Vascular contributions to cognitive impairment and dementia (VCID) are conditions arising from vascular diseases or abnormalities that result in cognitive impairments. Unfortunately, the pathophysiology of VCID remains to be elucidated. Qiu et al. used samples from patients with vascular dementia combined with experiments in a mouse model to show that tau containing a specific cis proline ( cis P-tau) was increased in the brain and played a major role in causing cognitive impairments. A cis P-tau–specific immunotherapy had therapeutic effects in the rodent model, whereas soluble cis P-tau administration caused neurodegeneration and brain dysfunction resembling VCID. The results suggest that targeting cis P-tau could reduce memory loss and neurodegeneration in VCID. Sci. Transl. Med. 13 , eaaz7615 (2021).
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