A practical preparation of α-hydroxy and α,β-dihydroxy aldehydes, useful intermediates for the synthesis of arachidonic acid metabolites, starting withD-glyceraldehyde acetonide

Abstract

Optically active α-hydroxy and α,β-dihydroxy aldehydes, useful intermediates for synthesis of lipoxygenase metabolites of arachidonic acid, are synthesized highly diastereoselectively starting with readily available D-glyceraldehyde acetonide.