A practical method for the combinatorial synthesis of peptide aldehydes

Abstract

A practical strategy for solid phase synthesis of peptide aldehydes is described. An olefin linker is constructed using Wittig chemistry, after peptide synthesis ozonolytic treatment of the linker and subsequent workup with dimethyl sulphide results in facile isolation of peptide aldehydes. The principle is demonstrated by synthesis of a 3×3×3 array of 27 tripeptide aldehydes.