Abstract
AbstractIn this update, we report a simple, mild and practical method for the synthesis of symmetrical urea via Lossen rearrangement promoted by SO2F2, which achieves the conversion from hydroxamic acid to symmetrical urea in high selectivity and provides a new method for facile initiation of Lossen rearrangement. Meanwhile, the reaction within amine or thiol also provide the efficient synthetic strategy towards unsymmetrical urea or thiocarbamates. Significant for gram‐scale application, we afford the desired product on gram‐scale by filtration without further purification. A plausible mechanism which is supported by control experimental and spectral data is proposed.
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