Abstract
The design and operating characteristics of a micro-type membrane cell as a differential detector for ionized compounds are described. The detector consists of two compartments separated by an ion-exchange membrane. The column effluent is passed through one compartment of the detector, and a reference electrolyte solution of the same composition as the eluent through the other. Changes in the composition of the solution in the measuring compartment bring about changes in the membrane potential. The performance of the detector was investigated under conditions prevailing in “classical” as well as dynamic solvent-generated ion-exchange chromatography. Experimental data on basic characteristics such as sensitivity, linearity, detection limits and dynamic behaviour are presented. The device has a detection limit in the nanomole range, provided that sufficiently diluted buffers are used as eluents. The linear working range is about 2-3 decades.
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