A potential role for integrins in host cell entry by SARS-CoV-2

Christian Ja Sigrist,Alan Bridge,Philippe Le Mercier

doi:10.1016/j.antiviral.2020.104759

Christian Ja Sigrist, Alan Bridge + Show 1 more

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https://doi.org/10.1016/j.antiviral.2020.104759

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Journal: Antiviral research	Publication Date: Mar 1, 2020
Citations: 280	License type: cc-by

Affiliation: SIB Swiss Institute of Bioinformatics

Abstract

• Integrin may act as an alternative receptor for SARS-CoV-2 and could be implicated in its transmission and pathology. • The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins. This motif is absent from other coronaviruses. • The integrin-binding motif is present at the surface of the spike protein, close to the ACE2 receptor-binding region. • Integrin binding may be a promising therapeutics target, and should be tested experimentally.

Highlights

Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source
SARS-CoV-2 belongs to the genus Betacoronavirus of the large family of Coronaviridae (“Betacoronavirus ~ ViralZone,” n.d.)
We suggest that SARS-CoV-2 may use integrins as cell receptors in one or more host species, binding to them through a conserved RGD (403–405: Arg-Gly-Asp) motif that is present in the receptor-binding domain of the spike proteins of all SARS-CoV-2 sequences analyzed to date (Fig. 2)

Summary

Introduction

Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. A potential role for integrins in host cell entry by SARS-CoV-2 We suggest that SARS-CoV-2 may use integrins as cell receptors in one or more host species, binding to them through a conserved RGD (403–405: Arg-Gly-Asp) motif that is present in the receptor-binding domain of the spike proteins of all SARS-CoV-2 sequences analyzed to date (Fig. 2).

Results

Conclusion