Abstract
Background:The emergence of chemotherapy resistant schistosomes necessitates finding new prophylaxis strategies based on immunization by using a modified vaccine candidate. Objective: To assess thepotential of an anti-schistosomal vaccine modified by nanotechnology. Materials and Methods: Soluble adult worm antigen preparation (SWAP) either crude or/and loaded on chitosan nanoparticles (CSNPs)were used. The anti-schistosomal impact was assessed in terms of stools egg count,worm burden and ultrastructural studyof juvenile and adult schistosomes. Results:Chitosan nanoparticles potentiated SWAP efficacy to exceed the impact of crude SWAP.The combination of SWAP loaded on CSNPs and crude SWAP showed the best immunization effects regarding adult worm number andfecundity,as well as morphological and tegumental distortion of juvenile than adult stages. Conclusion:Modified SWAP on CSNPs gave better results in anti-schistosome immunization thancrude SWAP.Immunization by combining different antigens gave the best results.
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