Abstract
Valinomycin inhibited cap formation induced by antibodies to Ig-molecules in human lymphocytes. At the concentration of valinomycin used in this study the inhibitory effects: (1) could not be explained by impaired cell viability, (2) were reversed by washing the drug from the medium and (3) were prevented by increasing the concentration of K + in the external medium. These results suggest that valinomycin may act, in part, by altering the electrical properties of the cell membrane and suggest a role for membrane potential and cation permeability and flux in the modulation of membrane receptors.
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