Abstract
The influence of pyridoxine upon the metabolic conversion of linoleic acid to arachidonic acid was studied in the livers of rats maintained w ith different kinds and conditions of dietary fats. In the basal diet group, the liver phospholipid fraction of the pyridoxine de ficient animals revealed significantly higher percentage of linoleic acid and sig nificantly lower percentage of arachidohic acid, when compared with the control group, whereas in the liver phospholipid fraction, the proportion of arachidonic acid was higher and that of eicosatrienoic acid significantly lower in the pyri doxine deficient group fed the hardening oil diet. Recovery experiments were carri ed out. The time course of changes in the fatty acid composition of the liver lipids of rats fed cotton-seed oil, after 6 weeks on a hardening oil diet, re vealed slower velocity of increase in arachidonate, slower velocity of decrease in eicosatrienoate and faster velocity of increase in linoleate in the pyridoxine de ficient group. Changes in the fatty acid composition of the liver phospholipid after giving r-linolenate to rats previously fed a fat free diet showed also slower velocity of increas e in arachidonate and lower velocity of decrease in eicosatrienoate. It is concluded that pyridoxine plays an important role in the essenti a l fatty acid metabolism, chiefly in the conversion of r-linolena te to arachidonate.
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