Abstract
Summary The effects of calcium (Ca ++ ) on the actions of glucagon, cAMP and dibutyryl cAMP on triacylglycerol synthesis, ketogenesis and output of glucose were studied using isolated hepatocytes. Glucagon, cAMP and Bt 2 cAMP decreased the incorporation of [1- 14 C]oleate into triacylglycerol and increased synthesis of ketone bodies and output of glucose. Basal rates of triacylglycerol synthesis, ketogenesis, and output of glucose, and the responses to glucagon and the cyclic nucleotides were diminished by depletion of calcium. Triacylglycerol synthesis was restored toward control values by treatment with calcium. Ionophore A 23187, mimicked the effects of glucagon on triacylglycerol biosynthesis provided calcium was present in the medium. Uptake of [1- 14 c]oleate was impaired when the hepatocytes were depleted of calcium. These observations suggest that calcium plays an important role in hepatic triacylglycerol synthesis and in ketogenesis and on the actions of glucagon and adenylic cyclic nucleotides on these metabolic pathways.
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