A Possible Relationship between Geographic Stomatitis and Psoriasis

Abstract

Geographic stomatitis (GS) is an uncommon oral lesion that presents clinical, histopathological, and genetic features similar to those of psoriasis. These findings suggest that GS may actually represent oral manifestations of psoriasis. A 37-year-old woman presented with red patches, surrounded by a white border on the labial mucosa, and a positive family history for psoriasis. Histopathological examination and immunohistochemical analysis for CD4; CD; CD20; CD68; CD31; and Ki-67, and the genotyping assay for HLA-A*; -B*; -C*; -DRB1*; -DQA1*; and -DQB1* revealed aspects compatible with psoriasis. Based on the findings, and due to the absence of cutaneous lesions, the diagnosis of GS was confirmed. This case and the theoretical data indicate that GS may represent an oral manifestation of psoriasis. Moreover, psoriatic patients should be routinely submitted to judicious oral examination, and patients with GS should be routinely submitted to cutaneous examination.