Abstract
Myelin-like figures or myeloid bodies occur in many tissues, especially after injury and with increasing age. The breathing of 100% oxygen also produces myeloid bodies.Tissues from rats exposed to 100% oxygen at one atmosphere for 72 hours were examined in the electron microscope. Samples from the brain, lung, spleen, heart and skeletal muscle, kidney and small intestine were fixed in glutaraldehyde, followed by osmium. Thin sections were stained in uranyl acetate and lead. Small myeloid figures which appeared as membrane pools, some showing Lamellae with about 45 Å spacing, were found in all the tissues examined. These figures were also found in the mitochondria and often gave the appearance of originating at this site (Figs. 1, 2, 3, 4). Invagination of membrane pooling occurs in places along the mitochondria. The various sizes of these membrane pools and possible extrusion and breakdown of the mitochondria suggests the mitochondria as a source of the myeloid bodies present after tissue damage from oxygen exposure.
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