Abstract
ObjectiveThis study was designed to assess the association between locus 7q11 rs1761667 polymorphism with incidence of preeclampsia in Egyptian pregnant women. MethodsThis study was conducted among 100 healthy pregnant subjects as control and 100 women presenting with preeclampsia. Different genotypes were identified by PCR-RFLP. Serum levels of soluble cluster of differentiation 36 (sCD-36), endocan, and other biochemical parameters were measured. ResultsHigh levels of sCD-36 were associated with preeclampsia, and the minor (A) allele of locus 7q11 genomic region rs1761667 polymorphism occured with higher frequency in preeclampsia patients than healthy subjects. Patients with AA genotype had significant increases in blood pressure, proteinuria, triglycerides, and total cholesterol. Serum endocan level was also higher in preeclampsia patients than healthy subjects. The levels of sCD-36 were positively correlated with those of endocan. ConclusionThe minor A allele of rs1761667 polymorphism G>A in chromosomal locus 7q11 is related to the increased risk of preeclampsia. Genotype AA is linked to high level of serum triglycerides and serum total cholesterol.
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