Abstract
Although family planning based on the use of contraceptive drugs and uterine devices is widely practised there are many women who, for various reasons, find these artefacts unacceptable. Control of family growth by periodic abstinence from intercourse during the fertile period has proved unreliable because of the viability of sperms and the difficulty of defining the fertile period. RIA methods for the measurement of steroid glucuronides can give useful warning of impending ovulation and of the duration of the fertile period. Of more practical value is the determination of the oestrone-3-glucuronide/pregnanediol-3α-glucuronide ratio which rises during the periovulatory period and falls sharply after the formation of the corpus luteum. This parameter does not depend on rate of excretion or on concentration
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