Abstract
Resveratrol, a polyphenolic compound found in the skin of red fruits, exhibits anti-inflammatory, anti-oxidative, and anti-proliferative characteristics. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine that also displays such properties. We therefore hypothesized that there might be a functional link between resveratrol and TGF-β. This study reports that resveratrol increased transcription of the TGF-β2 gene, enhanced the production of TGF-β2 protein, and activated Smad signaling in an autocrine manner in A549 human lung epithelial cell line. Thus, some of the beneficial effects of resveratrol on human health might be mediated, in part, through its effects on TGF-β expression and signaling.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
