Abstract
We reported that insulin sensitivity is inhibited by interruption of the hepatic parasympathetic reflex by surgical denervation of the liver or pharmacological blockade of the cholinergic neurotransmitter in rats (123). Therefore, we tested the hypothesis that parasympathetic neuropathy is associated with insulin resistance in type 2 diabetic patients. At the present time, only one method is available to directly measure autonomic nerve activity (4), and there are no methods available to measure hepatic parasympathetic nerve activity in humans. Thus, we used the deep breathing test to evaluate a cardiovascular parasympathetic nerve function. Hepatic parasympathetic neuropathy will often occur in parallel with cardiovascular parasympathetic neuropathy, because diabetic autonomic neuropathy is a systemic distal polyneuropathy. A total of 42 patients …
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
