Abstract
The newly formed corpus luteum of many species is refractory to the lytic action of prostaglandin F2alpha (PGF2alpha). This phenomenon was studied utilizing porcine, bovine and human granulosa-luteal cells in tissue culture. The steroidogenic potential of the granulosa-luteal cells was critical in determining whether PGF2alpha could inhibit progesterone production. Since the steroidogenic potential of the granulosa-luteal cell is related to the amount of LH bound to the cell, the bound LH may protect the granulosa-luteal cells from the lytic action of PGF2alpha. Finally, a 'see-saw' type of interaction between LH and PGF2alpha is postulated to account for the resistance of the newly formed corpus luteum to PGF2alpha.
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