Abstract
PURPOSE: Chronic thrombo-embolic pulmonary hypertension (CTEPH) is a debilitating and potentially fatal sequelae of acute pulmonary embolism. The etiology of CTEPH has not been determined, resulting in a lack of predictive or preventive strategies for CTEPH after acute pulmonary embolism. We speculate that the N-terminus of the fibrin beta chain (residues 15-21) is a potent stimulator of pulmonary endothelial cells and fibroblasts and could be involved in pulmonary vascular scarring in CTEPH. We studied fibrinogen purified from patients with CTEPH to determine the susceptibility of the beta chain N-terminus to lysis by plasmin.
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