A Positive Correlation between Hydrogen Peroxide and Soluble TNF-Alpha Receptor 2 Early in Maternal Blood and At Term in Placenta of Pregnant Women with Preeclampsia

Abstract

Objectives. We hypothesized that hydrogen peroxide (H2O2) and soluble TNF-α receptor 2 (sTNF-R2) co-play a role in the pathogenesis of preeclampsia. Methods. Correlation of H2O2 and sTNF-R2 was assessed in vivo in maternal blood and placenta, and in vitro in cytotrophoblasts culture. Results. We showed a positive correlation between increased levels of H2O2 and sTNF-R2 early at 10–15 gestational weeks and at term in maternal serum, and in placenta of women with preeclampsia. Our in vitro experiments showed that H2O2 induced the placental synthesis of sTNF-R2. Conclusion. We propose to consider H2O2 and sTNF-R2 as potential biomarkers in predicting preeclampsia.