Abstract
Recent studies using focused ultrasound (FUS) have shown significant progress in the realm of brain applications. These transcranial exposures include localized ablation for the treatment of movement disorders and opening of the blood brain barrier to enhance the delivery of therapeutic agents. Whereas these procedures require expensive, MRI-guided systems, one of the newest and most promising applications of FUS being developed involves more portable, hand-held devices for the purpose of neuromodulation. Here, we describe the development of table-top FUS system comprised of a single element FUS transducer (400—600 kHz) specifically for investigations on the stimulation and suppression of neuronal activity in rodents. The transducer assembly includes a cone and extending flexible bolus filled with degassed water for direct coupling to the head of the animals. A custom 3D stage and two diametrically opposed lasers allow for accurate positioning and targeting. Experiments included simulations of the acousti...
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