A porous Co-MOF for CO2 conversion and protective activity on infectious fever by reducing bacterial inflammatory response

Abstract

By applying a mixed-ligand approach based on an amino functionalized ligand 1-aminobenzene-3,4,5-tricarboxylic acid (H3abta), a novel metal-organic framework (MOF) containing Co(II) ion {[Co2.5(abta)(trz)2 (H2O)]·3H2O}n (1, Htrz = 1H-1,2,4-triazole) were produced via Co(NO3)2·6H2O reacting with H3abta with the existence of Htrz as the co-ligand. The prepared catalyst 1a (activated 1) is abundant in the amino groups and open metal sites (OMSs), which is helpful to obtain high CO2 capacity of adsorption around room temperature and effectively convert CO2 to pentacyclic carbamate with the help of Bu4NBr as the cocatalyst. For the treatment of infectious fever, the colony-forming unit (CFU) was performed and the E. coli number in the mice was counted. Next, the inflammatory cytokines level in the infected mice was measured after the compound treatment.