Abstract
Aim: The purpose of this study was to analyze the incidence, clinical characteristics, prognostic factors and survival of ovarian cancer patients with liver metastases upon initial diagnosis.Methods: Patients with ovarian cancer liver metastases upon initial diagnosis between 2010 and 2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate logistic regression was performed to identify the predictors of the presence of liver metastases in newly diagnosed ovarian cancer patients. Overall survival (OS) was assessed using the Kaplan-Meier method and log-rank test. Univariate and multivariate Cox regression was conducted to determine the independent prognostic factors for OS.Results: A total of 1,744 ovarian cancer patients with liver metastases was identified from the SEER database, accounting for 6.7% of the entire ovarian cancer patients. As to the unique distant organ provided by SEER, liver was the most common metastatic site of ovarian cancer (4.65%). Age, race, laterality, histology, pathological grade, extrahepatic sites, stage of tumor were the predictors of the presence with liver metastases revealed by multivariable logistic regression model. Median OS for the patients with liver metastases at initial diagnosis of ovarian cancer was 16.0 months. Multivariate Cox regression model confirmed race, histology, extrahepatic metastatic sites, surgery and marital status were independent prognostic factors for OS.Conclusion: The study provided population-based estimates of the incidence and prognosis of newly diagnosed ovary cancer patients with liver metastases, which could be potentially used for the risk assessment and individualized treatment.
Highlights
According to the latest cancer statistics in 2019, there were about 22,530 patients newly diagnosed with ovarian cancer and 13,980 patients died of ovarian cancer
Autopsy studies of cases died of primary ovarian cancer showed that the incidence of liver parenchyma was about 48.2–73% [5, 6]
All the primary data were acquired from the SEER database, which collected the information of patient demographics, tumor characteristics, treatment and prognosis accounting for ∼30% of the whole population in the United States
Summary
According to the latest cancer statistics in 2019, there were about 22,530 patients newly diagnosed with ovarian cancer and 13,980 patients died of ovarian cancer. Owing to the scarcity of early, specific symptoms and effective screening strategies, patients with ovarian cancer were often diagnosed with synchronous distant metastases at an advanced stage, accounting for about 70% of the whole ovarian cancer population [2]. Liver Metastases of Ovarian Cancer cancer patients was stage-dependent. Studies of the patterns of distant metastases in stage IV ovarian cancer showed liver was the most common distant metastatic organ of ovarian cancer with the proportion of 37–57%, followed by distant lymph nodes, lung, bone and brain [3,4,5]. The median overall survival (OS) was 30 months for patients with a single liver metastasis [4]
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