A population-based study of the relationship between endometrial thickness and prevalence of breast mass in postmenopausal women.

Abstract

To determine the relationship between endometrial thickness and the prevalence of breast mass in postmenopausal women. The prevalence of breast mass was investigated in 6759 postmenopausal women (≥60years) with different endometrial thicknesses who underwent breast and transvaginal ultrasonography from January 2015 to June 2017. Multivariable logistic regression analysis was used to obtain odds ratios and 95% confidence intervals for breast mass in postmenopausal women with increased endometrial thickness after adjusting for age, height, and body mass index. Compared with a baseline endometrial thickness of less than 3mm, the prevalence of breast mass increased in patients with endometrial thickness ≥3-4.9mm (OR 1.077; 95% CI, 0.868-1.338), ≥5-9.9mm (OR 1.910; 95% CI, 1.189-3.067), and ≥10mm (OR 3.546; 95% CI, 1.458-8.620) (Ptrend =0.0026). In subgroup analysis, correlations between endometrial thickness and prevalence of breast mass with malignant possibility (BI-RADS ≥3) were similar and remained significant (Ptrend =0.035). Postmenopausal women with endometrial thickness greater than or equal to 5mm have a significantly increased prevalence of breast mass and breast mass with malignant possibility (BI-RADS ≥3). Breast cancer screening for postmenopausal women with increased endometrial thickness should be given greater attention.