Abstract
Muscular dystrophies (MD) are a group of rare hereditary degenerative diseases. Our aim was to analyze the mortality pattern in Spain from 1981 to 2016 to assess the temporal trend and discern possible geographic differences using population-based data. Annual deaths related to MD were obtained from the National Statistics Institute with codes 359.1 of the ICD-9 (1981–1998) and G71.0 of the ICD-10 (1999–2016). Age-adjusted mortality rates were calculated and changes in mortality trends were identified. The standardized mortality ratios (SMR) and their respective 95% confidence intervals were calculated by district for 1999–2016. Smoothed SMRs and posterior probability were also assessed and then mapped to look for patterns or geographic distribution. All rates were expressed per 1,000,000 inhabitants. A total of 2,512 deaths (73.8% men) were identified. The age-adjusted mortality rates varied from 0.63 (95% CI 0.40–0.95) in 1981 to 1.51 (95% CI 1.17–1.93) in 2016. MD mortality showed a significant increase of 8.81% per year (95% CI 5.0–12.7) from 1981 to 1990, remaining stable afterwards. Areas with risk of death higher than expected for Spain as a whole were identified, not showing a specific regional pattern. In conclusion, the rising trend in MD mortality might be attributable to advanced improvements in diagnostic techniques leading to a rise in prevalence. Further research on the districts with the highest mortality would be necessary.
Highlights
Muscular dystrophies (MD) are a group of rare hereditary degenerative diseases
Abbreviations MD Muscular dystrophy DMD Duchenne muscular dystrophy NSI National Statistics Institute ICD International Classification of Diseases standardized mortality ratios (SMR) Standardized mortality ratios posterior probability (PP) Posterior probability 95% CI 95% Confidence interval
The registered annual deaths due to MD in the period 1981–2016 were obtained from the National Statistics Institute (NSI) of Spain
Summary
Muscular dystrophies (MD) are a group of rare hereditary degenerative diseases. Our aim was to analyze the mortality pattern in Spain from 1981 to 2016 to assess the temporal trend and discern possible geographic differences using population-based data. Abbreviations MD Muscular dystrophy DMD Duchenne muscular dystrophy NSI National Statistics Institute ICD International Classification of Diseases SMRs Standardized mortality ratios PP Posterior probability 95% CI 95% Confidence interval. Muscular dystrophies (MD) are a group of rare hereditary degenerative diseases that share clinical characteristics highlighting the progressive muscle weakness in the affected patients[1,2]. It encompasses a series of congenital disorders such as Duchenne or Becker, pelvic girdle, distal, facioscapulohumeral, Emery-Dreifuss, ocular and oculopharyngeal, among others. These disorders are differentiated by the age at which the first symptoms appear, the severity of the symptoms, the inheritance pattern and the affected muscles p attern[1]. Regarding the situation in Spain, the prevalence of MD is still unknown
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