Abstract
In the present study, a homogenous polysaccharide (DFPW) was isolated and purified from the dried rhizome of Drynaria fortunei, and its protective effect against osteoporosis was investigated in ovariectomized (OVX) rats. Histological analysis indicated that oral administration of DFPW (100 and 400 mg/kg) for 12 weeks significantly improved trabecular bone mass, as demonstrated by the increase in trabecular area, trabecular thickness and its number in OVX rats. Furthermore, the decline of bone mineral density and bone mineral content including Ca, P and Mg induced by OVX was reversed by the DFPW administration. This function was achieved by the decreased levels of the bone turnover markers, such as serum ALP, urinary deoxypyridinoline (DPD), Ca and P excretions. Besides, DFPW improved biomechanical parameters (maximum load, energy, Young's, modulus and maximum stress) to strengthen the hardness and strength femoral diaphysis in OVX rats. These results strongly suggested that DFPW might be a hopeful alternative therapeutics to treat postmenopausal osteoporosis.
Highlights
Osteoporosis is a metabolic bone disease, characterized by low bone mass and impaired microarchitecture of bone tissue, which increases bone frailty and susceptibility to the risk of fractures.[1,2] osteoporosis is widely reckoned as a major public health hazard, with high death rate and medical expenses throughout the world.[3]
There are still no available report concerning the study on the isolation and anti-osteoporosis activity of polysaccharide from D fortunei, a popular Traditional Chinese medicine (TCM) used to treated bone disorders in ancient time of China
We evaluated the effect of DFPW on biomechanical parameters of femoral diaphysis in OVX rats using three-point bending tests
Summary
Osteoporosis is a metabolic bone disease, characterized by low bone mass and impaired microarchitecture of bone tissue, which increases bone frailty and susceptibility to the risk of fractures.[1,2] osteoporosis is widely reckoned as a major public health hazard, with high death rate and medical expenses throughout the world.[3].
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