Abstract
BackgroundPlasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF.FindingsWe included 178 young patients with lone AF and the first episode before the age of 40 years, and a control group of 875 healthy individuals. We analyzed a promoter SNP (−131CG) (rs4950928) in the Chitinase 3–like 1 (CHI3L1) gene encoding YKL-40, which had previously been associated with elevated levels of YKL-40.ConclusionsThe (−131CG) genotype was not associated with increased risk of AF. Genetically increased YKL-40 levels were not associated to AF.
Highlights
The chitinase-like protein YKL-40 is emerging as a new biomarker of inflammation, which acts different and independent of C-reactive protein (CRP) [1]
We found no significant difference in the genotype distributions between the patients with lone atrial fibrillation (AF) and the healthy controls for the (−131CG) single nucleotide polymorphism (SNP) in Chitinase 3–like 1 (CHI3L1) (Table 1)
In genome wide association studies (GWAS) SNPs in the promoter region of the CHI3L1 gene have been associated with higher levels of YKL-40 in plasma [6]
Summary
The chitinase-like protein YKL-40 is emerging as a new biomarker of inflammation, which acts different and independent of C-reactive protein (CRP) [1]. Elevated plasma YKL-40 levels are seen in patients with diseases characterized by inflammation and ongoing tissue remodelling. We have recently shown that YKL-40 is elevated in patients with atrial fibrillation (AF) [2,3]. We hypothesized that a polymorphism in the chitinase3-like-1 gene (CHI3L1), coding for YKL-40 and known to be associated with elevated levels of YKL-40, could be associated with the risk of AF. We focused on patients with early onset lone AF as we assumed that the genetic component was relatively larger in these patients compared to older non-lone AF patients
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
