Abstract
AbstractA macromolecular prodrug of quinidine was synthesized by linking the amino ester of L‐phenylalanine with quinidine to carboxymethylcellulose via an amide bond. The release of the drug results from the hydrolysis of the ester linkage which occurs only in the presence of α‐chymotrypsin at pH 8. This specificity is relative to the nature of the ester derivative whose carboxylic moiety is an aromatic amino acid residue with L‐configuration. This prodrug contains 160 mg of quinidine per g of dry powder and allows a prolonged release (5–7 h) of the drug in an intestinal medium.
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