Abstract
Catheterization is a common medical operation for cardiovascular disease diagnosis and treatment, where low friction is attained through hydrophilic lubricious coatings. But these coatings can cause iatrogenic complications when particles become lose and float freely in the blood stream. Here we present an ultra-thin coating based on polyethylene glycol (PEG) functionalized hyaluronic acid (HA). The mussel-inspired biopolymer hyaluronic acid was first conjugated to dopamine (DN) to get HADN and then poly (ethylene glycol) bis (3-amino-propyl) terminated (PBA) was used to functionalize the HADN with PEG. The reciprocating sliding ball-on-flat ex vivo model based on PU ball and porcine aorta was used to evaluate the lubrication performance and the results suggest coating of HADN with best lubrication enhancement. After 40 min friction test, the surface of aorta remained intact for HADN-PBA coated PU as compared to HADN coating and positive control (sliding against bare PU). The amount of glycocalyx, number of endothelial nuclei and intima surface of aorta for coated PU were similar to negative control (without rubbing). Besides lubrication, the high biocompatibility suggests the coating of HADN-PBA is safe and lubrication benefits to the cardiovascular catheter.
Highlights
The function of many medical device and implant in biological systems depends on appropriate lubrication at the sliding interface.H
Besides lubrication the biocompatibility of this coating was checked and the results suggest the coating based on HADN and PBA can reduce the friction and resist wear of tissue, which benefit to cardiac catheterization application
40 mg hyaluronic acid (HA) was dissolved in 8 mL Phosphate Buffer solution (PBS) at pH 5 adjusted by hydrochloric acid (HCl)
Summary
Ho et al [17] reported a coating of poly (2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate [poly(MPC-co-BMA)] on PU surface yield a least friction due to the sufficient hydration and boundary lubrication enable by the polymer. The tribological and chemical characteristics of poly(MPC-co-BMA) increased the efficacy of PU for clinical applications. These studies mainly focus on the physical-chemical properties of the structure of materials itself rather than the real tissue. The effect of lubrication between coating and tissue remains unclear, which is quite important for clinical application. The aim of this study is to modify PU surface with an ultra-thin, stable and high biocompatibility coating to enhance sliding lubrication against blood vessel lumen
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